Cognitive deficits in Parkinson's disease: a cognitive neuroscience perspective.
Identifieur interne : 000634 ( Main/Exploration ); précédent : 000633; suivant : 000635Cognitive deficits in Parkinson's disease: a cognitive neuroscience perspective.
Auteurs : Trevor W. Robbins [Royaume-Uni] ; Roshan CoolsSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- complications : Parkinson Disease.
- diagnosis : Parkinson Disease.
- etiology : Cognition Disorders, Dementia.
- physiology : Cognition, Memory.
- physiopathology : Cognition Disorders, Dementia, Parkinson Disease.
- Animals, Humans.
Abstract
Progress in characterization of the nature, neural basis, and treatment of cognitive deficits in Parkinson's disease is reviewed from the perspective of cognitive neuroscience. An initial emphasis on fronto-striatal executive deficits is surveyed along with the discoveries of disruption as well as remediation of certain impairments by dopaminergic mediation and their association with theories of reinforcement learning. Subsequent focus on large cohorts has revealed considerable heterogeneity in the cognitive impairments as well as a suggestion of at least two distinct syndromes, with the dopamine-dependent fronto-striatal deficits being somewhat independent of other signs commonly associated with Parkinson's disease dementia. The utility is proposed of a new, integrated cognitive neuroscience approach based on combining genetic and neuroimaging methodologies with neuropsychological and, ultimately, psychopharmacological approaches.
DOI: 10.1002/mds.25853
PubMed: 24757109
Affiliations:
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Le document en format XML
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Robbins</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Cools, Roshan" sort="Cools, Roshan" uniqKey="Cools R" first="Roshan" last="Cools">Roshan Cools</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="doi">10.1002/mds.25853</idno><idno type="RBID">pubmed:24757109</idno><idno type="pmid">24757109</idno><idno type="wicri:Area/PubMed/Corpus">000530</idno><idno type="wicri:Area/PubMed/Curation">000530</idno><idno type="wicri:Area/PubMed/Checkpoint">000651</idno><idno type="wicri:Area/Ncbi/Merge">003F69</idno><idno type="wicri:Area/Ncbi/Curation">003F69</idno><idno type="wicri:Area/Ncbi/Checkpoint">003F69</idno><idno type="wicri:Area/Main/Merge">000634</idno><idno type="wicri:Area/Main/Curation">000634</idno><idno type="wicri:Area/Main/Exploration">000634</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cognitive deficits in Parkinson's disease: a cognitive neuroscience perspective.</title><author><name sortKey="Robbins, Trevor W" sort="Robbins, Trevor W" uniqKey="Robbins T" first="Trevor W" last="Robbins">Trevor W. Robbins</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Cools, Roshan" sort="Cools, Roshan" uniqKey="Cools R" first="Roshan" last="Cools">Roshan Cools</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cognition (physiology)</term><term>Cognition Disorders (etiology)</term><term>Cognition Disorders (physiopathology)</term><term>Dementia (etiology)</term><term>Dementia (physiopathology)</term><term>Humans</term><term>Memory (physiology)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term><term>Dementia</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cognition</term><term>Memory</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cognition Disorders</term><term>Dementia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Progress in characterization of the nature, neural basis, and treatment of cognitive deficits in Parkinson's disease is reviewed from the perspective of cognitive neuroscience. An initial emphasis on fronto-striatal executive deficits is surveyed along with the discoveries of disruption as well as remediation of certain impairments by dopaminergic mediation and their association with theories of reinforcement learning. Subsequent focus on large cohorts has revealed considerable heterogeneity in the cognitive impairments as well as a suggestion of at least two distinct syndromes, with the dopamine-dependent fronto-striatal deficits being somewhat independent of other signs commonly associated with Parkinson's disease dementia. The utility is proposed of a new, integrated cognitive neuroscience approach based on combining genetic and neuroimaging methodologies with neuropsychological and, ultimately, psychopharmacological approaches.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li></region><settlement><li>Cambridge</li></settlement><orgName><li>Université de Cambridge</li></orgName></list><tree><noCountry><name sortKey="Cools, Roshan" sort="Cools, Roshan" uniqKey="Cools R" first="Roshan" last="Cools">Roshan Cools</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Robbins, Trevor W" sort="Robbins, Trevor W" uniqKey="Robbins T" first="Trevor W" last="Robbins">Trevor W. Robbins</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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